Polyunsaturated Lipids Regulate Membrane Domain Stability by Tuning Membrane Order.

ABSTRACT: The plasma membrane (PM) serves as the functional interface between a cell and its environment, hosting extracellular signal transduction and nutrient transport among a variety of other processes. To support this extensive functionality, PMs are organized into lateral domains, including ordered, lipid-driven assemblies termed lipid rafts. Although the general requirements for ordered domain formation are well established, how these domains are regulated by cell-endogenous mechanisms or exogenous perturbations has not been widely addressed. In this context, an intriguing possibility is that dietary fats can incorporate into membrane lipids to regulate the properties and physiology of raft domains. Here, we investigate the effects of polyunsaturated fats on the organization of membrane domai

SUBMITTER: Levental KR 

PROVIDER: S-EPMC4850323 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature