Ontology highlight
ABSTRACT:
SUBMITTER: Giannakis M
PROVIDER: S-EPMC4850357 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Cell reports 20160414 4
Large-scale genomic characterization of tumors from prospective cohort studies may yield new insights into cancer pathogenesis. We performed whole-exome sequencing of 619 incident colorectal cancers (CRCs) and integrated the results with tumor immunity, pathology, and survival data. We identified recurrently mutated genes in CRC, such as BCL9L, RBM10, CTCF, and KLF5, that were not previously appreciated in this disease. Furthermore, we investigated the genomic correlates of immune-cell infiltrat ...[more]