Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H.
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ABSTRACT:
SUBMITTER: Xiao Q
PROVIDER: S-EPMC4850449 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
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Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H.
Xiao Qiang Q Dong Ningning N Yao Xue X Wu Dang D Lu Yanli Y Mao Fei F Zhu Jin J Li Jian J Huang Jin J Chen Aifang A Huang Lu L Wang Xuehai X Yang Guangxiao G He Guangyuan G Xu Yong Y Lu Weiqiang W
Scientific reports 20160429
Neutrophils play an important role in the occurrence and development of acute lung injury (ALI). Leukotriene B4 (LTB4), a hydrolysis product of epoxide leukotriene A4 (LTA4) catalyzed by LTA4 hydrolase (LTA4H), is one of the most potent chemoattractants for neutrophil. Bufexamac is a drug widely used as an anti-inflammatory agent on the skin, however, the mechanism of action is still not fully understood. In this study, we found bufexamac was capable of specifically inhibiting LTA4H enzymatic ac ...[more]
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