Impact of Intratumoral Inflammation on Survival After Pancreatic Cancer Resection.

ABSTRACT:

Objectives

Pancreatic cancer (PaC) frequently results in death despite surgical resection. We sought to evaluate whether inflammation in the primary tumor was associated with early death after surgical resection.

Methods

In this case-control study, we identified 21 individuals who died less than 12 months after surgery for PaC and 42 controls who survived more than 36 months after surgery. Differences in the composition of host inflammatory response between the groups were evaluated with univariate comparisons and odds ratios for early death were calculated using logistic regression modeling.

Results

Cases were more likely to have a high tumor grade (90.5% vs 26.2%; P < 0.01). The odds of early death were increased in those with a high-grade tumor (unadjusted odds rat

SUBMITTER: Hart PA 

PROVIDER: S-EPMC4850490 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature