Ontology highlight
ABSTRACT:
SUBMITTER: Carocci M
PROVIDER: S-EPMC4850914 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Carocci Margot M Yang Priscilla L PL
Antiviral research 20160210
Dengue virus, a member of the Flaviviridae family, is a mosquito-borne pathogen and the causative agent of dengue fever. Despite the nearly 400 million new infections estimated annually, no vaccines or specific antiviral therapeutics are currently available. We identified lactimidomycin (LTM), a recently established inhibitor of translation elongation, as a potent inhibitor of dengue virus 2 infection in cell culture. The antiviral activity is observed at concentrations that do not affect cell v ...[more]