Ontology highlight
ABSTRACT:
SUBMITTER: Ouspenskaia T
PROVIDER: S-EPMC4850916 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Ouspenskaia Tamara T Matos Irina I Mertz Aaron F AF Fiore Vincent F VF Fuchs Elaine E
Cell 20160101 1-2
Adult stem cell (SC) maintenance and differentiation are known to depend on signals received from the niche. Here, however, we demonstrate a mechanism for SC specification and regulation that is niche independent. Using immunofluorescence, live imaging, genetics, cell-cycle analyses, in utero lentiviral transduction, and lineage-tracing, we show that in developing hair buds, SCs are born from asymmetric divisions that differentially display WNT and SHH signaling. Displaced WNT(lo) suprabasal dau ...[more]