D-Cycloserine in Neuropsychiatric Diseases: A Systematic Review.
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ABSTRACT:
SUBMITTER: Schade S
PROVIDER: S-EPMC4851259 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Publications
D-Cycloserine in Neuropsychiatric Diseases: A Systematic Review.
Schade Sebastian S Paulus Walter W
The international journal of neuropsychopharmacology 20160420 4
D-Cycloserine, known from tuberculosis therapy, has been widely introduced to neuropsychiatric studies, since its central active mechanism as a partial NMDA-agonist has been found. In this review, we evaluate its therapeutic potential in neuropsychological disorders and discuss its pitfalls in terms of dosing and application frequency as well as its safety in low-dose therapy. Therefore, we identified 91 clinical trials by performing a Medline search. We demonstrate in part preliminary but incre ...[more]
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