Ontology highlight
ABSTRACT:
SUBMITTER: Lin XL
PROVIDER: S-EPMC4851335 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Lin Xiao-Li XL Niu De D Hu Zi-Liang ZL Kim Dae Heon DH Jin Yin Hua YH Cai Bin B Liu Peng P Miura Kenji K Yun Dae-Jin DJ Kim Woe-Yeon WY Lin Rongcheng R Jin Jing Bo JB
PLoS genetics 20160429 4
COP1 (CONSTITUTIVE PHOTOMORPHOGENIC 1), a ubiquitin E3 ligase, is a central negative regulator of photomorphogenesis. However, how COP1 activity is regulated by post-translational modifications remains largely unknown. Here we show that SUMO (small ubiquitin-like modifier) modification enhances COP1 activity. Loss-of-function siz1 mutant seedlings exhibit a weak constitutive photomorphogenic phenotype. SIZ1 physically interacts with COP1 and mediates the sumoylation of COP1. A K193R substitution ...[more]