A Zebrafish Genetic Screen Identifies Neuromedin U as a Regulator of Sleep/Wake States.
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ABSTRACT:
SUBMITTER: Chiu CN
PROVIDER: S-EPMC4851465 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
A Zebrafish Genetic Screen Identifies Neuromedin U as a Regulator of Sleep/Wake States.
Chiu Cindy N CN Rihel Jason J Lee Daniel A DA Singh Chanpreet C Mosser Eric A EA Chen Shijia S Sapin Viveca V Pham Uyen U Engle Jae J Niles Brett J BJ Montz Christin J CJ Chakravarthy Sridhara S Zimmerman Steven S Salehi-Ashtiani Kourosh K Vidal Marc M Schier Alexander F AF Prober David A DA
Neuron 20160201 4
Neuromodulation of arousal states ensures that an animal appropriately responds to its environment and engages in behaviors necessary for survival. However, the molecular and circuit properties underlying neuromodulation of arousal states such as sleep and wakefulness remain unclear. To tackle this challenge in a systematic and unbiased manner, we performed a genetic overexpression screen to identify genes that affect larval zebrafish arousal. We found that the neuropeptide neuromedin U (Nmu) pr ...[more]
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