Ontology highlight
ABSTRACT:
SUBMITTER: Bath PM
PROVIDER: S-EPMC4852111 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Bath Philip M PM Woodhouse Lisa L Krishnan Kailash K Anderson Craig C Berge Eivind E Ford Gary A GA Robinson Thompson G TG Saver Jeffrey L JL Sprigg Nikola N Wardlaw Joanna M JM In Acute Stroke Collaboration Basc Blood Pressure BP
Stroke research and treatment 20160417
Background. Nitric oxide (NO) donors are a candidate treatment for acute stroke and two trials have suggested that they might improve outcome if administered within 4-6 hours of stroke onset. We assessed the safety and efficacy of NO donors using individual patient data (IPD) from completed trials. Methods. Randomised controlled trials of NO donors in patients with acute or subacute stroke were identified and IPD sought from the trialists. The effect of NO donor versus control on functional outc ...[more]