Ontology highlight
ABSTRACT:
SUBMITTER: Putman AH
PROVIDER: S-EPMC4852167 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Putman A H AH Wolen A R AR Harenza J L JL Yordanova R K RK Webb B T BT Chesler E J EJ Miles M F MF
Genes, brain, and behavior 20160401 4
Genetic differences in acute behavioral responses to ethanol contribute to the susceptibility to alcohol use disorder and the reduction of anxiety is a commonly reported motive underlying ethanol consumption among alcoholics. Therefore, we studied the genetic variance in anxiolytic-like responses to ethanol across the BXD recombinant inbred (RI) mouse panel using the light-dark transition model of anxiety. Strain-mean genetic mapping and a mixed-model quantitative trait loci (QTL) analysis repli ...[more]