Ontology highlight
ABSTRACT:
SUBMITTER: Romere C
PROVIDER: S-EPMC4852710 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Cell 20160414 3
Hepatic glucose release into the circulation is vital for brain function and survival during periods of fasting and is modulated by an array of hormones that precisely regulate plasma glucose levels. We have identified a fasting-induced protein hormone that modulates hepatic glucose release. It is the C-terminal cleavage product of profibrillin, and we name it Asprosin. Asprosin is secreted by white adipose, circulates at nanomolar levels, and is recruited to the liver, where it activates the G ...[more]