Ontology highlight
ABSTRACT:
SUBMITTER: Toyama EQ
PROVIDER: S-EPMC4852862 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Toyama Erin Quan EQ Herzig Sébastien S Courchet Julien J Lewis Tommy L TL Losón Oliver C OC Hellberg Kristina K Young Nathan P NP Chen Hsiuchen H Polleux Franck F Chan David C DC Shaw Reuben J RJ
Science (New York, N.Y.) 20160101 6270
Mitochondria undergo fragmentation in response to electron transport chain (ETC) poisons and mitochondrial DNA-linked disease mutations, yet how these stimuli mechanistically connect to the mitochondrial fission and fusion machinery is poorly understood. We found that the energy-sensing adenosine monophosphate (AMP)-activated protein kinase (AMPK) is genetically required for cells to undergo rapid mitochondrial fragmentation after treatment with ETC inhibitors. Moreover, direct pharmacological a ...[more]