Ontology highlight
ABSTRACT:
SUBMITTER: Carroll EC
PROVIDER: S-EPMC4852885 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Immunity 20160302 3
The cationic polysaccharide chitosan is an attractive candidate adjuvant capable of driving potent cell-mediated immunity, but the mechanism by which it acts is not clear. We show that chitosan promotes dendritic cell maturation by inducing type I interferons (IFNs) and enhances antigen-specific T helper 1 (Th1) responses in a type I IFN receptor-dependent manner. The induction of type I IFNs, IFN-stimulated genes and dendritic cell maturation by chitosan required the cytoplasmic DNA sensor cGAS ...[more]