Ontology highlight
ABSTRACT:
SUBMITTER: Chater-Diehl EJ
PROVIDER: S-EPMC4852908 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Chater-Diehl Eric J EJ Laufer Benjamin I BI Castellani Christina A CA Alberry Bonnie L BL Singh Shiva M SM
PloS one 20160502 5
The molecular basis of Fetal Alcohol Spectrum Disorders (FASD) is poorly understood; however, epigenetic and gene expression changes have been implicated. We have developed a mouse model of FASD characterized by learning and memory impairment and persistent gene expression changes. Epigenetic marks may maintain expression changes over a mouse's lifetime, an area few have explored. Here, mice were injected with saline or ethanol on postnatal days four and seven. At 70 days of age gene expression ...[more]