Ontology highlight
ABSTRACT:
SUBMITTER: Roberts RA
PROVIDER: S-EPMC4852957 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Roberts Reid A RA Eitas Timothy K TK Byrne James D JD Johnson Brandon M BM Short Patrick J PJ McKinnon Karen P KP Reisdorf Shannon S Luft J Christopher JC DeSimone Joseph M JM Ting Jenny P JP
Biomaterials 20150820
The possibility of engineering the immune system in a targeted fashion using biomaterials such as nanoparticles has made considerable headway in recent years. However, little is known as to how modulating the spatial presentation of a ligand augments downstream immune responses. In this report we show that geometric manipulation of phosphatidylserine (PS) through fabrication on rod-shaped PLGA nanoparticles robustly dampens inflammatory responses from innate immune cells while promoting T regula ...[more]