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Serotonin as a New Therapeutic Target for Diabetes Mellitus and Obesity.

ABSTRACT: Serotonin (5-hydroxytryptamine [5-HT]) is a monoamine that has various functions in both neuronal and non-neuronal systems. In the central nervous system, 5-HT regulates mood and feeding behaviors as a neurotransmitter. Thus, there have been many trials aimed at increasing the activity of 5-HT in the central nervous system, and some of the developed methods are already used in the clinical setting as anti-obesity drugs. Unfortunately, some drugs were withdrawn due to the development of unwanted peripheral side effects, such as valvular heart disease and pulmonary hypertension. Recent studies revealed that peripheral 5-HT plays an important role in metabolic regulation in peripheral tissues, where it suppresses adaptive thermogenesis in brown adipose tissue. Inhibition of 5-HT synthesis reduced the weight gain and improved the metabolic dysfunction in a diet-induced obesity mouse model. Genome-wide association studies also revealed genetic associations between the serotonergic system and obesity. Several genetic polymorphisms in tryptophan hydroxylase and 5-HT receptors were shown to have strong associations with obesity. These results support the clinical significance of the peripheral serotonergic system as a therapeutic target for obesity and diabetes.

SUBMITTER: Oh CM

PROVIDER: S-EPMC4853228 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Serotonin as a New Therapeutic Target for Diabetes Mellitus and Obesity.

Oh Chang Myung CM Park Sangkyu S Kim Hail H

Diabetes & metabolism journal 20160401 2

Serotonin (5-hydroxytryptamine [5-HT]) is a monoamine that has various functions in both neuronal and non-neuronal systems. In the central nervous system, 5-HT regulates mood and feeding behaviors as a neurotransmitter. Thus, there have been many trials aimed at increasing the activity of 5-HT in the central nervous system, and some of the developed methods are already used in the clinical setting as anti-obesity drugs. Unfortunately, some drugs were withdrawn due to the development of unwanted ...[more]

PMID: 27126880

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Dataset Information

Serotonin as a New Therapeutic Target for Diabetes Mellitus and Obesity.

Publications

Serotonin as a New Therapeutic Target for Diabetes Mellitus and Obesity.

Similar Datasets

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