Dataset Information

A dosimetric comparison of real-time adaptive and non-adaptive radiotherapy: A multi-institutional study encompassing robotic, gimbaled, multileaf collimator and couch tracking.

ABSTRACT:

Purpose

A study of real-time adaptive radiotherapy systems was performed to test the hypothesis that, across delivery systems and institutions, the dosimetric accuracy is improved with adaptive treatments over non-adaptive radiotherapy in the presence of patient-measured tumor motion.

Methods and materials

Ten institutions with robotic(2), gimbaled(2), MLC(4) or couch tracking(2) used common materials including CT and structure sets, motion traces and planning protocols to create a lung and a prostate plan. For each motion trace, the plan was delivered twice to a moving dosimeter; with and without real-time adaptation. Each measurement was compared to a static measurement and the percentage of failed points for ?-tests recorded.

Results

For all lung traces all measurement sets show improved dose accuracy with a mean 2%/2mm ?-fail rate of 1.6% with adaptation and 15.2% without adaptation (p<0.001). For all prostate the mean 2%/2mm ?-fail rate was 1.4% with adaptation and 17.3% without adaptation (p<0.001). The difference between the four systems was small with an average 2%/2mm ?-fail rate of <3% for all systems with adaptation for lung and prostate.

Conclusions

The investigated systems all accounted for realistic tumor motion accurately and performed to a similar high standard, with real-time adaptation significantly outperforming non-adaptive delivery methods.

SUBMITTER: Colvill E

PROVIDER: S-EPMC4854175 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Publications

A dosimetric comparison of real-time adaptive and non-adaptive radiotherapy: A multi-institutional study encompassing robotic, gimbaled, multileaf collimator and couch tracking.

Colvill Emma E Booth Jeremy J Nill Simeon S Fast Martin M Bedford James J Oelfke Uwe U Nakamura Mitsuhiro M Poulsen Per P Worm Esben E Hansen Rune R Ravkilde Thomas T Scherman Rydhög Jonas J Pommer Tobias T Munck Af Rosenschold Per P Lang Stephanie S Guckenberger Matthias M Groh Christian C Herrmann Christian C Verellen Dirk D Poels Kenneth K Wang Lei L Hadsell Michael M Sothmann Thilo T Blanck Oliver O Keall Paul P

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20160322 1

<h4>Purpose</h4>A study of real-time adaptive radiotherapy systems was performed to test the hypothesis that, across delivery systems and institutions, the dosimetric accuracy is improved with adaptive treatments over non-adaptive radiotherapy in the presence of patient-measured tumor motion.<h4>Methods and materials</h4>Ten institutions with robotic(2), gimbaled(2), MLC(4) or couch tracking(2) used common materials including CT and structure sets, motion traces and planning protocols to create ...[more]

PMID: 27016171

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Dataset Information

A dosimetric comparison of real-time adaptive and non-adaptive radiotherapy: A multi-institutional study encompassing robotic, gimbaled, multileaf collimator and couch tracking.

Purpose

Methods and materials

Results

Conclusions

Publications

A dosimetric comparison of real-time adaptive and non-adaptive radiotherapy: A multi-institutional study encompassing robotic, gimbaled, multileaf collimator and couch tracking.

Similar Datasets

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