Ontology highlight
ABSTRACT:
SUBMITTER: Flavell RR
PROVIDER: S-EPMC4854293 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Flavell Robert R RR Truillet Charles C Regan Melanie K MK Ganguly Tanushree T Blecha Joseph E JE Kurhanewicz John J VanBrocklin Henry F HF Keshari Kayvan R KR Chang Christopher J CJ Evans Michael J MJ Wilson David M DM
Bioconjugate chemistry 20151222 1
Solid tumors are hypoxic with altered metabolism, resulting in secretion of acids into the extracellular matrix and lower relative pH, a feature associated with local invasion and metastasis. Therapeutic and diagnostic agents responsive to this microenvironment may improve tumor-specific delivery. Therefore, we pursued a general strategy whereby caged small-molecule drugs or imaging agents liberate their parent compounds in regions of low interstitial pH. In this manuscript, we present a new aci ...[more]