Ontology highlight
ABSTRACT:
SUBMITTER: Shen Y
PROVIDER: S-EPMC4854516 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Shen Yu Y Wen Quan Q Liu He H Zhong Connie C Qin Yuqi Y Harris Gareth G Kawano Taizo T Wu Min M Xu Tianqi T Samuel Aravinthan Dt AD Zhang Yun Y
eLife 20160503
As a common neurotransmitter in the nervous system, γ-aminobutyric acid (GABA) modulates locomotory patterns in both vertebrates and invertebrates. However, the signaling mechanisms underlying the behavioral effects of GABAergic modulation are not completely understood. Here, we demonstrate that a GABAergic signal in C. elegans modulates the amplitude of undulatory head bending through extrasynaptic neurotransmission and conserved metabotropic receptors. We show that the GABAergic RME head motor ...[more]