Ontology highlight
ABSTRACT:
SUBMITTER: Takeo Y
PROVIDER: S-EPMC4855140 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Scientific reports 20160504
The ability of radial glial progenitors (RGPs) to generate cortical neurons is determined by local extracellular factors and signaling pathways intrinsic to RGPs. Here we find that GPR157, an orphan G protein-coupled receptor, localizes to RGPs' primary cilia exposed to the cerebrospinal fluid (CSF). GPR157 couples with Gq-class of the heterotrimeric G-proteins and signals through IP3-mediated Ca(2+) cascade. Activation of GPR157-Gq signaling enhances neuronal differentiation of RGPs whereas int ...[more]