Ontology highlight
ABSTRACT:
SUBMITTER: Kim DJ
PROVIDER: S-EPMC4855275 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Experimental & molecular medicine 20160429
p21-activated kinases (PAKs) are key regulators of actin dynamics, cell proliferation and cell survival. Deregulation of PAK activity contributes to the pathogenesis of various human diseases, including cancer and neurological disorders. Using an ELISA-based screening protocol, we identified naphtho(hydro)quinone-based small molecules that allosterically inhibit PAK activity. These molecules interfere with the interactions between the p21-binding domain (PBD) of PAK1 and Rho GTPases by binding t ...[more]