Ontology highlight
ABSTRACT:
SUBMITTER: Min B
PROVIDER: S-EPMC4856087 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Min Byungkuk B Cho Sunwha S Park Jung Sun JS Jeon Kyuheum K Kang Yong-Kook YK
G3 (Bethesda, Md.) 20160503 5
Epigenetic reprogramming is necessary in somatic cell nuclear transfer (SCNT) embryos in order to erase the differentiation-associated epigenetic marks of donor cells. However, such epigenetic memories often persist throughout the course of clonal development, thus decreasing cloning efficiency. Here, we explored reprogramming-refractory regions in bovine SCNT blastocyst transcriptomes. We observed that histone genes residing in the 1.5 Mb spanning the cow HIST1 cluster were coordinately downreg ...[more]