Ontology highlight
ABSTRACT:
SUBMITTER: Topol A
PROVIDER: S-EPMC4856588 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Topol Aaron A Zhu Shijia S Hartley Brigham J BJ English Jane J Hauberg Mads E ME Tran Ngoc N Rittenhouse Chelsea Ann CA Simone Anthony A Ruderfer Douglas M DM Johnson Jessica J Readhead Ben B Hadas Yoav Y Gochman Peter A PA Wang Ying-Chih YC Shah Hardik H Cagney Gerard G Rapoport Judith J Gage Fred H FH Dudley Joel T JT Sklar Pamela P Mattheisen Manuel M Cotter David D Fang Gang G Brennand Kristen J KJ
Cell reports 20160421 5
Converging evidence indicates that microRNAs (miRNAs) may contribute to disease risk for schizophrenia (SZ). We show that microRNA-9 (miR-9) is abundantly expressed in control neural progenitor cells (NPCs) but also significantly downregulated in a subset of SZ NPCs. We observed a strong correlation between miR-9 expression and miR-9 regulatory activity in NPCs as well as between miR-9 levels/activity, neural migration, and diagnosis. Overexpression of miR-9 was sufficient to ameliorate a previo ...[more]