Drosha and Dicer: Slicers cut from the same cloth.
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ABSTRACT:
SUBMITTER: Li S
PROVIDER: S-EPMC4856758 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Drosha and Dicer: Slicers cut from the same cloth.
Cell research 20160429 5
DROSHA and its partner DGCR8 form a heterotrimeric complex named Microprocessor, which is essential for microRNA biogenesis. A recent study by Kwon et al. in Cell reveals the structure of a DROSHA construct in complex with the C-terminal region of DGCR8, thereby unveiling the topology and interactions between components of the Microprocessor and insights into its 'ruler'-based cleavage activity and function. ...[more]
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