Ontology highlight
ABSTRACT:
SUBMITTER: Sivanesam K
PROVIDER: S-EPMC4857621 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Sivanesam Kalkena K Andersen Niels H NH
Current neuropharmacology 20160101 3
Alpha-Synuclein is found in the neuronal cells but its native function is not well known. While α -synuclein is an intrinsically disordered protein that adopts a helical conformation upon membrane binding, numerous studies have shown that oligomeric β-forms of this protein are cytotoxic. This response to misfolded species contributes to Parkinson's Disease etiology and symptoms. The resulting amyloid fibrils are an established diagnostic in Parkinson's Disease. In this review, we focus on strate ...[more]