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Network Meta-Analysis of Onychomycosis Treatments.

ABSTRACT: BACKGROUND:Many onychomycosis treatments have not been directly compared in head-to-head clinical trials. OBJECTIVE:To determine the relative efficacy of onychomycosis treatments using network meta-analysis (NMA). METHODS:We conducted a systematic review and NMA of mycological cure rates. RESULTS:Nineteen trials were included in the network. Terbinafine 250 mg was significantly superior to all treatments except itraconazole 400 mg pulse therapy. The itraconazole 400 mg pulse regimen was significantly superior to all topicals except efinaconazole 10% nail solution. Itraconazole 200 mg was significantly superior to all topical treatments, while fluconazole 150-450 mg, efinaconazole 10% nail solution, tavaborole 5% nail solution, ciclopirox nail lacquer 8%, terbinafine nail solution, and amorolfine 5% nail lacquer were significantly superior to placebo. CONCLUSIONS:Newly developed topicals have improved the odds ratios (ORs) of mycological cure, yet these ORs were not significantly greater than preexisting topical treatments. Further experience with these agents will reveal their clinical significance, and head-to-head trials are warranted. © 2015 S. Karger AG, Basel.

SUBMITTER: Gupta AK

PROVIDER: S-EPMC4857825 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Network Meta-Analysis of Onychomycosis Treatments.

Gupta Aditya K AK Daigle Deanne D Foley Kelly A KA

Skin appendage disorders 20150626 2

<h4>Background</h4>Many onychomycosis treatments have not been directly compared in head-to-head clinical trials.<h4>Objective</h4>To determine the relative efficacy of onychomycosis treatments using network meta-analysis (NMA).<h4>Methods</h4>We conducted a systematic review and NMA of mycological cure rates.<h4>Results</h4>Nineteen trials were included in the network. Terbinafine 250 mg was significantly superior to all treatments except itraconazole 400 mg pulse therapy. The itraconazole 400 ...[more]

PMID: 27170937

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Network Meta-Analysis of Onychomycosis Treatments.

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Network Meta-Analysis of Onychomycosis Treatments.

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