Ontology highlight
ABSTRACT:
SUBMITTER: Wu H
PROVIDER: S-EPMC4858255 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Wu Hao H Xie Markus M MM Liu Hong H Dent Alexander L AL
PloS one 20160505 5
The production of antibody is precisely controlled during the germinal center (GC) reaction. This process is dependent on the help from follicular T helper (Tfh) cells to germinal center (GC) B cells and is regulated by regulatory follicular T helper (Tfr) cells. How Tfr cells develop and how their suppressive activity functions are not well understood. Here, we found that Stat3 is indispensible for Tfr cell differentiation. After immunization with Sheep Red Blood Cells (SRBC), the loss of Tfr c ...[more]