Ontology highlight
ABSTRACT:
SUBMITTER: Ratliff ML
PROVIDER: S-EPMC4858324 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Ratliff Michelle L ML Mishra Meenu M Frank Mark B MB Guthridge Joel M JM Webb Carol F CF
Journal of immunology (Baltimore, Md. : 1950) 20151218 2
We recently reported that the transcription factor ARID3a is expressed in a subset of human hematopoietic progenitor stem cells in both healthy individuals and in patients with systemic lupus erythematosus. Numbers of ARID3a(+) lupus hematopoietic stem progenitor cells were associated with increased production of autoreactive Abs when those cells were introduced into humanized mouse models. Although ARID3a/Bright knockout mice died in utero, they exhibited decreased numbers of hematopoietic stem ...[more]