Ontology highlight
ABSTRACT:
SUBMITTER: Gibbs-Seymour I
PROVIDER: S-EPMC4858568 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Molecular cell 20160407 3
We report the identification of histone PARylation factor 1 (HPF1; also known as C4orf27) as a regulator of ADP-ribosylation signaling in the DNA damage response. HPF1/C4orf27 forms a robust protein complex with PARP-1 in cells and is recruited to DNA lesions in a PARP-1-dependent manner, but independently of PARP-1 catalytic ADP-ribosylation activity. Functionally, HPF1 promotes PARP-1-dependent in trans ADP-ribosylation of histones and limits DNA damage-induced hyper-automodification of PARP-1 ...[more]