Widespread 3'-end uridylation in eukaryotic RNA viruses.
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ABSTRACT:
SUBMITTER: Huo Y
PROVIDER: S-EPMC4858684 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Widespread 3'-end uridylation in eukaryotic RNA viruses.
Huo Yayun Y Shen Jianguo J Wu Huanian H Zhang Chao C Guo Lihua L Yang Jinguang J Li Weimin W
Scientific reports 20160506
RNA 3' uridylation occurs pervasively in eukaryotes, but is poorly characterized in viruses. In this study, we demonstrate that a broad array of RNA viruses, including mycoviruses, plant viruses and animal viruses, possess a novel population of RNA species bearing nontemplated oligo(U) or (U)-rich tails, suggesting widespread 3' uridylation in eukaryotic viruses. Given the biological relevance of 3' uridylation to eukaryotic RNA degradation, we propose a conserved but as-yet-unknown mechanism in ...[more]
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