Widespread 3'-end uridylation in eukaryotic RNA viruses.

ABSTRACT: RNA 3' uridylation occurs pervasively in eukaryotes, but is poorly characterized in viruses. In this study, we demonstrate that a broad array of RNA viruses, including mycoviruses, plant viruses and animal viruses, possess a novel population of RNA species bearing nontemplated oligo(U) or (U)-rich tails, suggesting widespread 3' uridylation in eukaryotic viruses. Given the biological relevance of 3' uridylation to eukaryotic RNA degradation, we propose a conserved but as-yet-unknown mechanism in virus-host interaction.

SUBMITTER: Huo Y 

PROVIDER: S-EPMC4858684 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature