Dchs1-Fat4 regulation of polarized cell behaviours during skeletal morphogenesis.
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ABSTRACT:
SUBMITTER: Mao Y
PROVIDER: S-EPMC4858749 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Dchs1-Fat4 regulation of polarized cell behaviours during skeletal morphogenesis.
Mao Yaopan Y Kuta Anna A Crespo-Enriquez Ivan I Whiting Danielle D Martin Tina T Mulvaney Joanna J Irvine Kenneth D KD Francis-West Philippa P
Nature communications 20160505
Skeletal shape varies widely across species as adaptation to specialized modes of feeding and locomotion, but how skeletal shape is established is unknown. An example of extreme diversity in the shape of a skeletal structure can be seen in the sternum, which varies considerably across species. Here we show that the Dchs1-Fat4 planar cell polarity pathway controls cell orientation in the early skeletal condensation to define the shape and relative dimensions of the mouse sternum. These changes fi ...[more]
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