Ontology highlight
ABSTRACT:
SUBMITTER: Huebner AR
PROVIDER: S-EPMC4858939 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Molecular & cellular proteomics : MCP 20160216 5
Exosomes, derived from multivesicular bodies (MVBs), contain proteins and genetic materials from their cell of origin and are secreted from various cells types, including kidney epithelial cells. In general, it is thought that protein cargo is ubiquitylated but that ubiquitin is cleaved by specific deubiquitylases during the process of cargo incorporation into MVBs. Here, we provide direct evidence that, in vivo, deubiquitylation is not essential. Ubiquitin was detected within human MVBs and uri ...[more]