Ontology highlight
ABSTRACT:
SUBMITTER: Zou W
PROVIDER: S-EPMC4859220 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Zou Weiping W Wolchok Jedd D JD Chen Lieping L
Science translational medicine 20160301 328
PD-L1 and PD-1 (PD) pathway blockade is a highly promising therapy and has elicited durable antitumor responses and long-term remissions in a subset of patients with a broad spectrum of cancers. How to improve, widen, and predict the clinical response to anti-PD therapy is a central theme in the field of cancer immunology and immunotherapy. Oncologic, immunologic, genetic, and biological studies focused on the human cancer microenvironment have yielded substantial insight into this issue. Here, ...[more]