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Why p-OMe- and p-Cl-?-Methylphenethylamines Display Distinct Activities upon MAO-B Binding.

ABSTRACT: Despite their structural and chemical commonalities, p-chloro-?-methylphenethylamine and p-methoxy-?-methylphenethylamine display distinct inhibitory and substrate activities upon MAO-B binding. Density Functional Theory (DFT) quantum chemical calculations reveal that ?-methylation and para-substitution underpin the observed activities sustained by calculated transition state energy barriers, attained conformations and key differences in their interactions in the enzyme's substrate binding site. Although both compounds meet substrate requirements, it is clear that ?-methylation along with the physicochemical features of the para-substituents on the aromatic ring determine the activity of these compounds upon binding to the MAO B-isoform. While data for a larger set of compounds might lend generality to our conclusions, our experimental and theoretical results strongly suggest that the contrasting activities displayed depend on the conformations adopted by these compounds when they bind to the enzyme.

SUBMITTER: Fierro A

PROVIDER: S-EPMC4859490 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Why p-OMe- and p-Cl-β-Methylphenethylamines Display Distinct Activities upon MAO-B Binding.

Fierro Angélica A Edmondson Dale E DE Celis-Barros Cristian C Rebolledo-Fuentes Marco M Zapata-Torres Gerald G

PloS one 20160506 5

Despite their structural and chemical commonalities, p-chloro-β-methylphenethylamine and p-methoxy-β-methylphenethylamine display distinct inhibitory and substrate activities upon MAO-B binding. Density Functional Theory (DFT) quantum chemical calculations reveal that β-methylation and para-substitution underpin the observed activities sustained by calculated transition state energy barriers, attained conformations and key differences in their interactions in the enzyme's substrate binding site. ...[more]

PMID: 27152414

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Dataset Information

Why p-OMe- and p-Cl-?-Methylphenethylamines Display Distinct Activities upon MAO-B Binding.

Publications

Why p-OMe- and p-Cl-β-Methylphenethylamines Display Distinct Activities upon MAO-B Binding.

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