Ontology highlight
ABSTRACT:
SUBMITTER: Zaman S
PROVIDER: S-EPMC4859694 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Molecular and cellular biology 20160502 10
The NAD-dependent histone deacetylase Sir2 controls ribosomal DNA (rDNA) silencing by inhibiting recombination and RNA polymerase II-catalyzed transcription in the rDNA of Saccharomyces cerevisiae Sir2 is recruited to nontranscribed spacer 1 (NTS1) of the rDNA array by interaction between the RENT ( RE: gulation of N: ucleolar S: ilencing and T: elophase exit) complex and the replication terminator protein Fob1. The latter binds to its cognate sites, called replication termini (Ter) or replicati ...[more]