Gestational Diabetes Mellitus Is Strongly Associated With Non-Alcoholic Fatty Liver Disease.

ABSTRACT:

Objectives

Insulin resistance is central to the development of non-alcoholic fatty liver disease (NAFLD), and gestational diabetes mellitus (GDM) is an early marker of insulin resistance. We hypothesized that a history of GDM would identify women at higher risk of NAFLD in middle age.

Methods

Women from the multicenter Coronary Artery Risk Development in Young Adults (CARDIA) cohort study who delivered ≥1 birth, were free of diabetes prior to pregnancy(ies), and underwent CT quantification of hepatic steatosis 25 years following cohort entry (Y25: 2010-2011) were included (n=1,115). History of GDM by self-report, validated in a subsample by review of antenatal glucose testing, and metabolic risk factors were assessed prospectively. NAFLD was defined by liver attenuation (LA)

SUBMITTER: Ajmera VH 

PROVIDER: S-EPMC4860097 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature