Ontology highlight
ABSTRACT:
SUBMITTER: Barthelme D
PROVIDER: S-EPMC4860136 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Barthelme Dominik D Sauer Robert T RT
Journal of molecular biology 20151201 9 Pt B
The AAA+ Cdc48 ATPase (alias p97 or VCP) is a key player in multiple ubiquitin-dependent cell signaling, degradation, and quality control pathways. Central to these broad biological functions is the ability of Cdc48 to interact with a large number of adaptor proteins and to remodel macromolecular proteins and their complexes. Different models have been proposed to explain how Cdc48 might couple ATP hydrolysis to forcible unfolding, dissociation, or remodeling of cellular clients. In this review, ...[more]