Ontology highlight
ABSTRACT:
SUBMITTER: Wang XF
PROVIDER: S-EPMC4860285 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Wang Xue-Feng XF Liu Jing-Jing JJ Xia Julia J Liu Ji J Mirabella Vincent V Pang Zhiping P ZP
Cell reports 20150723 5
Glucagon-like peptide-1 (GLP-1) and its analogs act as appetite suppressants and have been proven to be clinically efficacious in reducing body weight in obese individuals. Central GLP-1 is expressed in a small population of brainstem cells located in the nucleus tractus solitarius (NTS), which project to a wide range of brain areas. However, it remains unclear how endogenous GLP-1 released in the brain contributes to appetite regulation. Using chemogenetic tools, we discovered that central GLP- ...[more]