Ontology highlight
ABSTRACT:
SUBMITTER: Branchfield K
PROVIDER: S-EPMC4860346 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20160107 6274
The lung is constantly exposed to environmental atmospheric cues. How it senses and responds to these cues is poorly defined. Here, we show that Roundabout receptor (Robo) genes are expressed in pulmonary neuroendocrine cells (PNECs), a rare, innervated epithelial population. Robo inactivation in mouse lung results in an inability of PNECs to cluster into sensory organoids and triggers increased neuropeptide production upon exposure to air. Excess neuropeptides lead to an increase in immune infi ...[more]