Ontology highlight
ABSTRACT:
SUBMITTER: Moshfegh C
PROVIDER: S-EPMC4860597 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Moshfegh Cameron C Aires Lina L Kisielow Malgorzata M Vogel Viola V
Scientific reports 20160509
Embryonic stem (ES) cells share markers with undifferentiated primordial germ cells (PGCs). Here, we discovered that a cellular state with some molecular markers of male gonocyte induction, including a G1/S phase arrest and upregulation of specific genes such as Nanos2, Tdrd1, Ddx4, Zbtb16 and Plk1s1, can be chemically induced in male mouse ES cells in vitro, which we termed gonogenic stimulated transition (GoST). After longer culture of the resulting GoST cells without chemical stimulation, sev ...[more]