Genome Hotspots for Nucleotide Substitutions and the Evolution of Influenza A (H1N1) Human Strains.
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ABSTRACT:
SUBMITTER: Civetta A
PROVIDER: S-EPMC4860693 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
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Genome Hotspots for Nucleotide Substitutions and the Evolution of Influenza A (H1N1) Human Strains.
Civetta Alberto A Ostapchuk David Cecil Murphy DC Nwali Basil B
Genome biology and evolution 20160408 4
In recent years a number of studies have brought attention to the role of positive selection during the evolution of antigenic escape by influenza strains. Particularly, the identification of positively selected sites within antigenic domains of viral surface proteins has been used to suggest that the evolution of viral-host receptor binding specificity is driven by selection. Here we show that, following the 1918 outbreak, the antigenic sites of the hemagglutinin (HA) viral surface protein and ...[more]
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