Ontology highlight
ABSTRACT:
SUBMITTER: Rosin L
PROVIDER: S-EPMC4861639 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Rosin Leah L Mellone Barbara G BG
Developmental cell 20160401 2
Centromeres mediate the conserved process of chromosome segregation, yet centromeric DNA and the centromeric histone, CENP-A, are rapidly evolving. The rapid evolution of Drosophila CENP-A loop 1 (L1) is thought to modulate the DNA-binding preferences of CENP-A to counteract centromere drive, the preferential transmission of chromosomes with expanded centromeric satellites. Consistent with this model, CENP-A from Drosophila bipectinata (bip) cannot localize to Drosophila melanogaster (mel) centr ...[more]