Ontology highlight
ABSTRACT:
SUBMITTER: Zhou PH
PROVIDER: S-EPMC4861819 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Zhou Pang-Hu PH Hu Wei W Zhang Xiao-Bin XB Wang Wei W Zhang Li-Jun LJ
Mediators of inflammation 20160426
This study was carried out to investigate whether ADM can modulate LPS-induced inflammation and apoptosis in rat Leydig cells. Leydig cells were treated with ADM before LPS-induced cytotoxicity. We determined the concentrations of ROS, MDA, GSH, LDH, and testosterone and the MMP. The mRNA levels of IL-1, IL-6, iNOS, and COX-2 were obtained, and the concentrations of IL-1, IL-6, NO, and PGE2 were determined. Apoptosis was assessed by TUNEL and detection of DNA fragmentation. The levels of mRNA an ...[more]