Ontology highlight
ABSTRACT:
SUBMITTER: Sanders MA
PROVIDER: S-EPMC4862007 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Sanders Matthew A MA Madoux Franck F Mladenovic Ljiljana L Zhang Huamei H Ye Xiangqun X Angrish Michelle M Mottillo Emilio P EP Caruso Joseph A JA Halvorsen Geoff G Roush William R WR Chase Peter P Hodder Peter P Granneman James G JG
Cell metabolism 20150924 5
Fat and muscle lipolysis involves functional interactions of adipose triglyceride lipase (ATGL), α-β hydrolase domain-containing protein 5 (ABHD5), and tissue-specific perilipins 1 and 5 (PLIN1 and PLIN5). ABHD5 potently activates ATGL, but this lipase-promoting activity is suppressed when ABHD5 is bound to PLIN proteins on lipid droplets. In adipocytes, protein kinase A (PKA) phosphorylation of PLIN1 rapidly releases ABHD5 to activate ATGL, but mechanisms for rapid regulation of PLIN5-ABHD5 int ...[more]