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Plasmacytoid dendritic cells in allogeneic hematopoietic cell transplantation: benefit or burden?

ABSTRACT: Plasmacytoid dendritic cells (pDCs) bridge innate and adaptive immune responses and have important roles in hematopoietic engraftment, GvHD and graft-versus-leukemia responses following allogeneic hematopoietic cell transplantation (HCT). In addition, pDCs mediate antiviral immunity, particularly as they are the body's primary cellular source of type I interferon. Given their pleiotropic roles, pDCs have emerged as cells that critically impact transplant outcomes, including overall survival. In this article, we will review the pre-clinical and clinical literature, supporting the crucial roles that pDCs assume as key immune effector cells during HCT.

SUBMITTER: Auletta JJ

PROVIDER: S-EPMC4862020 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Plasmacytoid dendritic cells in allogeneic hematopoietic cell transplantation: benefit or burden?

Auletta J J JJ Devine S M SM Waller E K EK

Bone marrow transplantation 20151207 3

Plasmacytoid dendritic cells (pDCs) bridge innate and adaptive immune responses and have important roles in hematopoietic engraftment, GvHD and graft-versus-leukemia responses following allogeneic hematopoietic cell transplantation (HCT). In addition, pDCs mediate antiviral immunity, particularly as they are the body's primary cellular source of type I interferon. Given their pleiotropic roles, pDCs have emerged as cells that critically impact transplant outcomes, including overall survival. In ...[more]

PMID: 26642333

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