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Conflict of interest and signal interference lead to the breakdown of honest signaling.

ABSTRACT: Animals use signals to coordinate a wide range of behaviors, from feeding offspring to predator avoidance. This poses an evolutionary problem, because individuals could potentially signal dishonestly to coerce others into behaving in ways that benefit the signaler. Theory suggests that honest signaling is favored when individuals share a common interest and signals carry reliable information. Here, we exploit the opportunities offered by bacterial signaling to test these predictions with an experimental evolution approach. We show that: (1) reduced relatedness leads to the relative breakdown of signaling, (2) signaling breaks down by the invasion of mutants that show both reduced signaling and reduced response to signal, (3) the genetic route to signaling breakdown is variable, and (4) the addition of artificial signal, to interfere with signal information, also leads to reduced signaling. Our results provide clear support for signaling theory, but we did not find evidence for previously predicted coercion at intermediate relatedness, suggesting that mechanistic details can alter the qualitative nature of specific predictions. Furthermore, populations evolved under low relatedness caused less mortality to insect hosts, showing how signal evolution in bacterial pathogens can drive the evolution of virulence in the opposite direction to that often predicted by theory.

SUBMITTER: Popat R

PROVIDER: S-EPMC4862024 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Conflict of interest and signal interference lead to the breakdown of honest signaling.

Popat Roman R Pollitt Eric J G EJ Harrison Freya F Naghra Hardeep H Hong Kar-Wai KW Chan Kok-Gan KG Griffin Ashleigh S AS Williams Paul P Brown Sam P SP West Stuart A SA Diggle Stephen P SP

Evolution; international journal of organic evolution 20150908 9

Animals use signals to coordinate a wide range of behaviors, from feeding offspring to predator avoidance. This poses an evolutionary problem, because individuals could potentially signal dishonestly to coerce others into behaving in ways that benefit the signaler. Theory suggests that honest signaling is favored when individuals share a common interest and signals carry reliable information. Here, we exploit the opportunities offered by bacterial signaling to test these predictions with an expe ...[more]

PMID: 26282874

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Project description:BACKGROUND:The division of reproductive labor among group members in insect societies is regulated by "queen pheromones". However, it remains controversial whether these are manipulative, i.e., actively suppress worker reproduction, or honestly signal the fertility status of the queen to which workers react in their own interest by refraining from laying eggs. Manipulative queen control is thought to lead to an evolutionary arms race between queens and workers, resulting in complex queen bouquets that diverge strongly among different populations and species. In contrast, honest signals would evolve more slowly and might therefore differ less strongly within and among species. RESULTS:We aimed at determining the tempo of the evolution of queen signals in two ways. First, we investigated whether queens of Temnothorax ants are capable of controlling egg laying by workers of their own, closely, and distantly related species. Second, we compared the species- and caste-specific patterns of cuticular hydrocarbons, which are assumed to convey information on reproductive status. In mixed-species colonies, queens were not able to fully suppress egg-laying and male production by workers of unrelated species, while workers did not reproduce under the influence of a queen from their own species. Furthermore, the chemical profiles differed more strongly among queens of different species than among the respective workers. CONCLUSIONS:Our results suggest that cuticular hydrocarbons associated with fecundity are not fully conserved in evolution and evolve slightly faster than worker-specific components in the blend of cuticular hydrocarbons. While this higher rate of evolution might reflect an arms race between queens and workers, the observation that workers still respond to the presence of a queen from another species support the honest signal hypothesis. Future studies need to examine alternative explanations for a higher rate of evolution of queen-specific substances, such as an involvement of such compounds in mating.

Project description:ObjectivesTo assess Italian medical oncologists' opinion on the implications of conflict of interest (COI) on medical education, care and research, and to evaluate their direct financial relationships.DesignNational cross-sectional survey conducted between March and April 2017 among Italian oncologists.SettingOnline survey sponsored by the Italian College of Medical Oncology Chiefs through its website.ParticipantsItalian oncologists who filled out an anonymous questionnaire including 19 items and individual and working characteristics.Main outcome measureThe proportion of medical oncologists perceiving COI as an outstanding issue and those receiving direct payments from industry.ResultsThere were 321 respondents, representing 13% of Italian tenured medical oncologists. Overall, 62% declared direct payments from the pharmaceutical industry in the last 3 years. Sixty-eight per cent felt the majority of Italian oncologists have a COI with industry, but 59% suppose this is not greater than that of other specialties. Eighty-two per cent consider that most oncology education is supported by industry. More than 75% believe that current allocation of industry budget on marketing and promotion rather than research and development is unfair, but 75% consider it appropriate to receive travel and lodging hospitality from industry. A median net profit margin of €5000 per patient enrolled in an industry trial was considered appropriate for the employee institution. Sixty per cent agree to receive a personal fee for patients enrolled in industry trials, but 79% state this should be reported in the informed consent. Over 90% believe that scientific societies should publish a financial report of industry support. Finally, 79% disagree to being a coauthor of an article written by a medical writer when no substantial scientific contribution is made.ConclusionsAmong Italian oncologists COI is perceived as an important issue influencing costs, education, care and science. A more rigorous policy on COI should be implemented.

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Conflict of interest and signal interference lead to the breakdown of honest signaling.

Publications

Conflict of interest and signal interference lead to the breakdown of honest signaling.

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