Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation.
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ABSTRACT:
SUBMITTER: Celiz AD
PROVIDER: S-EPMC4862031 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Publications
Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation.
Celiz Adam D AD Smith James G W JG Patel Asha K AK Hook Andrew L AL Rajamohan Divya D George Vinoj T VT Flatt Luke L Patel Minal J MJ Epa Vidana C VC Singh Taranjit T Langer Robert R Anderson Daniel G DG Allen Nicholas D ND Hay David C DC Winkler David A DA Barrett David A DA Davies Martyn C MC Young Lorraine E LE Denning Chris C Alexander Morgan R MR
Advanced materials (Deerfield Beach, Fla.) 20150601 27
A scalable and cost-effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial media is presented. This substrate can be applied to common cultureware and used off-the-shelf after long-term storage. Expansion and differentiation of hPSCs are performed entirely on the polymeric surface, enabling the clinical potential of hPSC-derived cells to be realized. ...[more]
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