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ABSTRACT: Objective
The primary objective of this research was to characterize the movement disorders associated with FOXG1 mutations.Methods
We identified patients with FOXG1 mutations who were referred to either a tertiary movement disorder clinic or tertiary epilepsy service and retrospectively reviewed medical records, clinical investigations, neuroimaging, and available video footage. We administered a telephone-based questionnaire regarding the functional impact of the movement disorders and perceived efficacy of treatment to the caregivers of one cohort of participants.Results
We identified 28 patients with FOXG1 mutations, of whom 6 had previously unreported mutations. A wide variety of movement disorders were identified, with dystonia, choreoathetosis, and orolingual/facial dyskinesias most commonly present. Ninety-three percent of patients had a mixed movement disorder phenotype. In contrast to the phenotype classically described with FOXG1 mutations, 4 patients with missense mutations had a milder phenotype, with independent ambulation, spoken language, and normocephaly. Hyperkinetic involuntary movements were a major clinical feature in these patients. Of the symptomatic treatments targeted to control abnormal involuntary movements, most did not emerge as clearly beneficial, although 4 patients had a caregiver-reported response to levodopa.Conclusions
Abnormal involuntary movements are a major feature of FOXG1 mutations. Our study delineates the spectrum of movement disorders and confirms an expanding clinical phenotype. Symptomatic treatment may be considered for severe or disabling cases, although further research regarding potential treatment strategies is necessary.
SUBMITTER: Papandreou A
PROVIDER: S-EPMC4862244 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Papandreou Apostolos A Schneider Ruth B RB Augustine Erika F EF Ng Joanne J Mankad Kshitij K Meyer Esther E McTague Amy A Ngoh Adeline A Hemingway Cheryl C Robinson Robert R Varadkar Sophia M SM Kinali Maria M Salpietro Vincenzo V O'Driscoll Margaret C MC Basheer S Nigel SN Webster Richard I RI Mohammad Shekeeb S SS Pula Shpresa S McGowan Marian M Trump Natalie N Jenkins Lucy L Elmslie Frances F Scott Richard H RH Hurst Jane A JA Perez-Duenas Belen B Paciorkowski Alexander R AR Kurian Manju A MA
Neurology 20160330 19
<h4>Objective</h4>The primary objective of this research was to characterize the movement disorders associated with FOXG1 mutations.<h4>Methods</h4>We identified patients with FOXG1 mutations who were referred to either a tertiary movement disorder clinic or tertiary epilepsy service and retrospectively reviewed medical records, clinical investigations, neuroimaging, and available video footage. We administered a telephone-based questionnaire regarding the functional impact of the movement disor ...[more]