Ontology highlight
ABSTRACT:
SUBMITTER: Kumar A
PROVIDER: S-EPMC4862330 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Kumar Abhishek A Ouyang Mingxing M Van den Dries Koen K McGhee Ewan James EJ Tanaka Keiichiro K Anderson Marie D MD Groisman Alexander A Goult Benjamin T BT Anderson Kurt I KI Schwartz Martin A MA
The Journal of cell biology 20160501 3
Integrin-dependent adhesions are mechanosensitive structures in which talin mediates a linkage to actin filaments either directly or indirectly by recruiting vinculin. Here, we report the development and validation of a talin tension sensor. We find that talin in focal adhesions is under tension, which is higher in peripheral than central adhesions. Tension on talin is increased by vinculin and depends mainly on actin-binding site 2 (ABS2) within the middle of the rod domain, rather than ABS3 at ...[more]